Hyperbaric oxygen therapy (HBOT) is used to treat a variety of diseases and injuries, particularly those where increased oxygen delivery can enhance healing or combat complications. It’s FDA-approved for conditions like chronic non-healing wounds (e.g., diabetic foot ulcers), carbon monoxide poisoning, decompression sickness (common in divers), and gas gangrene caused by bacterial infections. HBOT is also widely recognized for treating radiation injuries, such as tissue damage from cancer treatments, and severe burns by promoting tissue regeneration. It’s effective for crush injuries and acute traumatic ischemia, where it reduces swelling and prevents tissue death. Beyond these, HBOT is used off-label or in research for traumatic brain injuries (TBI), stroke, cerebral palsy, and multiple sclerosis to potentially improve neurological outcomes. Infections like osteomyelitis (bone infections) or necrotizing fasciitis benefit from its antimicrobial effects. Emerging applications include support for Lyme disease, autism, and even anti-aging. Its versatility stems from its ability to accelerate healing, reduce inflammation, and enhance oxygen supply to compromised tissues.